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KMID : 0606920070150010027
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Biomolecules & Therapeutics
2007 Volume.15 No. 1 p.27 ~ p.33
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Anxiolytic and Antidepressant Activities of Ginsenoside Rb1
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Choi Jong-Hyun
Yoon Seo-Young
Choi Eun-Joo
Ryu Yim-Seon
Ko Hong-Sook
Yim Dong-Sool
Her Youl
Lee Yong-Soo
Song Mi-Ryoung
Cheong Jae-Hoon
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Abstract
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The psychopharmacological profile of ginsenosides has not yet been confirmed systematically although various neuropharmacological activities associated with them have been investigated. In the present study, the psychological activities of Rb1 were investigated to evaluate whether it can be used in treatment or prevention of psychological disorders. Rb1 was intravenously injected at doses of O.2,2,5 and 10 mg/kg. The effects of Rb1 on the $Cl^-$ ion influx were investigated using IMR-32 human neuroblastoma cells. Moreover, locomotor activity, forced swimming activity, activity on rotating rod and activity in elevated plus-maze were tested in mice. Rb1 increased the $Cl^-$ influx into the intracell region in a dose-dependent manner. Rb1 did not cause change in behavior in total open field when locomotor activity was tested, however it increased activities, especially, such as rearing frequency in center area. Administration of Rb1 at 0.2 mg/kg significantly reduced activities on rotating rod however administration at high dosages had no effect on them. Rb1 administration decreased animal immobile time in a water chamber in a dose dependent manner, and increased the strong mobile time of animals. In conclusion, the present results demonstrate that Rb1 contributes to the psychopharmacological effects of ginseng and may be used in treatment or prevention of psychological disorders such as anxiety or depression.
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KEYWORD
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ginsenoside Rb1, anxiolytic, antidepressant
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